How Long Psilocybin Stays in Your System

Psilocybin, a naturally occurring psychedelic compound found in certain mushrooms, has gained significant attention for its potential therapeutic benefits and mind-altering effects. As its popularity grows, many people are curious about how long psilocybin stays in your system. This article explores the half-life of psilocybin, examining factors such as metabolism, dosage, and frequency of use. By providing a comprehensive overview, it aims to inform anyone interested in understanding this intriguing compound better.

What are Psilocybin Mushrooms?

The term “psilocybin mushrooms” refers to over 200 naturally occurring species of mushrooms found all over the world. These mushrooms have active compounds like psilocybin and psilocin. They are ingested orally, either in food or in a brew, and once you synthesize said compound, you experience hallucinations of various types. This is why people also call them psychedelic mushrooms or magic mushrooms. Even though they have very few physical adverse side effects, it is still important to know how long they take to exit your system. As they can stay in it for 24 hours or more, you can accidentally end up taking a larger dose than you meant to. This can lead to negative psychological effects. Some states also legally penalize you if a test proves it has been in your system or if the police catches you in possession of them.

Some mushrooms in a forest
Different species of psilocybin mushrooms contain varying concentrations of psilocybin and psilocin.

What Are the Effects of Shrooms?

Psilocybin mushrooms, commonly known as shrooms, produce a variety of effects that can vary greatly depending on the dose, individual, and environment. Some of the most common effects include:

  • Euphoria: Users often experience a profound sense of happiness and well-being.
  • Altered Perception of Time: Time may seem to slow down or speed up.
  • Visual and Auditory Hallucinations: Shrooms can cause vivid visual distortions, such as seeing patterns, shapes, and colors, as well as altered sounds.
  • Changes in Thought Patterns: Users may experience deep, introspective thoughts, enhanced creativity, and a sense of connectedness with the universe.
  • Emotional Intensity: Emotions can become more intense and change rapidly.
  • Spiritual Experiences: Many users report mystical or spiritual experiences, feeling a sense of unity or oneness.
  • Physiological Effects: These can include nausea, increased heart rate, dilated pupils, and changes in blood pressure.

While many of these effects can be positive, shrooms can also cause negative experiences, especially if taken in high doses or in an uncomfortable setting. These negative effects can include:

  • Some users may experience intense fear or paranoia.
  • High doses can lead to confusion and disorientation.
  • Negative hallucinations or a sense of losing control can result in a bad trip.

The effects of shrooms typically begin within 20 to 40 minutes of ingestion and can last for up to 6 hours, with the peak occurring around 2 to 3 hours after consumption. It is important to use them responsibly and in a safe environment to minimize the risk of adverse effects.

a woman in distress
High doses of psilocybin can lead to confusion, disorientation, and paranoia.

How Long Psilocybin Stays in Your System: Decisive Factors

Determining how long psilocybin mushrooms stay in your body is complex and influenced by several factors such as metabolism, body composition, dosage, frequency of use, species of mushroom, method of use, how much you’ve eaten and drank, and other substances in your system. Here’s a breakdown of these decisive factors:

Metabolism and Body Composition

The concept you have of metabolism is probably the process by which your body submits food and other edibles to eventually eliminate them. While this is partially true, the same process of metabolism that is used to eliminate takes place when metabolizing the active compound is used to convert the psilocybin or psilocin into an active compound similar to serotonin. Enzymes break down in your liver in the case of said components. If you have liver issues, you may be putting said organ on overtime. This can play a decisive role in how quickly psilocybin mushrooms exit your system. If you have a shorter metabolism, psilocybin may be detectable for shorter periods.

Regarding body composition, we are talking about how fat, muscle, tissue, and water are distributed in your body. Psilocybin and psilocin are both lipophilic. This means they quickly and easily adhere to fat. If you have a lot of fat, it may remain in your body for longer. Please note that someone’s size doesn’t necessarily correlate to how much fat they have available in their body. There are many people on the bigger side whose composition is more leaning towards muscle than fat, and conversely, many people with smaller frames have very fatty body compositions. If you have a lot of fat, psilocybin will be detectable in your samples for longer. This is why it’s important to take this factor into account.

Psilocybin mushrooms in black and white
How long psilocybin stays in your system can vary significantly between individuals.

Dosage and Frequency of Use

Higher doses of the drug mean the body has more to synthesize. This means more work for the liver and more potential for psilocybin or psilocin to be stored in the fat present in your body. Higher or more frequent doses than usual also means you could potentially develop a tolerance to the drug. Even though physical tolerance to psilocybin mushrooms is technically possible, it is very rare.

However, there is still a palpable risk of developing psychological dependence on the substance. This is especially the case for people who have a history of substance abuse. If you develop psychological tolerance, you will crave higher and higher doses each time, and this can affect other factors, such as metabolism.

Species of Mushroom

Different species of psilocybin mushrooms contain varying concentrations of psilocybin and psilocin, which can influence how long they stay in your system. Some species may have higher potency, leading to longer detection times.

Method of Use

The way you consume psilocybin mushrooms—whether eating them raw, brewed as a tea, or taken in a capsule—can impact how quickly the compounds are absorbed and metabolized by your body.

How Much You’ve Eaten and Drank

Food and drink intake can affect the absorption rate of psilocybin. Consuming mushrooms on an empty stomach may lead to quicker absorption and faster onset of effects, while a full stomach can slow this process down.

Other Substances in Your System

The presence of other substances, including medications, alcohol, and prescription drugs, can interact with psilocybin and influence how it is metabolized and eliminated. These interactions can either speed up or slow down the process.

If you have been using other substances and find yourself struggling with addiction, it is crucial to seek help. Programs such as a CBT treatment plan for substance abuse can provide effective strategies for managing addiction and improving mental health. Addressing substance use issues comprehensively can significantly enhance your overall well-being and aid in recovery.

Type of Testing Method

To determine how long psilocybin mushrooms have been in your system, the most common method is a urine test. However, other testing options include hair, saliva, and blood tests. These tests can only identify if psilocybin was consumed within a certain timeframe, not the exact time of ingestion.

In a lab, professionals analyze bodily fluids or tissues to detect signs of psilocybin mushrooms. The specific indicators they look for vary depending on the sample type. Each testing method uses different techniques, which affect how long psilocybin is detectable in the body.

a lab tech holding a bottle with a blue liquid to determine how long psilocybin stays in your system
The most common method for detecting psilocybin is urine testing.


Urine testing is the go-to detection method for psilocybin mushrooms. Psilocybin and its metabolites are excreted in urine after ingestion. It can be found in a urine sample in various ways, including:

  • immunoassay screening tests
  • gas chromatography-mass spectrometry (GC-MS)
  • liquid chromatography-mass spectrometry (LC-MS)

In the case of urine testing, psilocybin can be detected a few days to a week after digestion. metabolism, body distribution, dose, and frequency of use influences for how many days psilocybin is present in urine.


Blood testing may be performed in the case of medical emergencies or forensic investigations. For example, suppose your medical history indicates you have a history of using psilocybin mushrooms, and you’re unconscious after a medical emergency. In that case, doctors may draw a blood sample, so they don’t give you drugs that interact negatively with psilocybin mushrooms.


This testing method is only used when there’s a need to know about long-term psilocybin use. As hair grows, psilocybin and its metabolites can be present in the hair follicles. Therefore, it can be used to tell whether the patient has used it in a timeframe spanning a few weeks to a few months. When in that time period psilocybin was used cannot be known with this method of testing, just that the patient has used psilocybin in a certain time period.


This testing method may be the preferred option for workplace testing and roadside drug testing. Psilocybin and its metabolites can be found in saliva shortly after ingestion. Psilocybin is detectable in saliva a few hours after ingestion. Detection times are generally short-lived in this method of testing.

Risks and Considerations

There are several risks to using psilocybin mushrooms. They include legal consequences, as carrying, ingesting, buying, and selling psilocybin mushrooms are all punishable by law. There are also health (including mental health) consequences to taking psilocybin mushrooms, which we will discuss in detail below. If you find yourself tempted to experiment with psilocybin mushrooms or other substances, you may consider getting treatment for substance use. Various programs, such as those offered at a drug rehab center in Pennsylvania, can provide the necessary support.

Legal Consequences

Psilocybin is a Schedule I substance in the United States. This means that the government recognizes it as a highly addictive substance without any proven medical use. Therefore, there are legal risks to carrying Psilocybin mushrooms, buying, selling, and ingesting them.

What’s the Penalty for Having Psilocybin Mushrooms in Your System?

The actual penalties may, however, vary by state. In Pennsylvania, possession of a small amount of Psilocybin mushrooms for personal use is considered a misdemeanor. It can end up putting you in jail for one year or a $5,000 fine. If you are in possession of a larger amount and have an intent to distribute, it is a felony in PA. Trying to sell them means in a higher time of imprisonment and more expensive fines, though the severity of the penalty may change according to factors such as your criminal history.

All of these charges apply if you test positive for Psilocybin while detained by police. If you’re on parole or probation, this can affect you negatively and put you back in jail. Suppose you test positive, and your employer has access to these results. In that case, this can result in job loss, especially if your workplace is drug-free or involves safety-sensitive duties. First-time offenders may face less strict penalties but may still have to complete court-ordered drug rehabilitation, education programs, and mandated community services.

a lab technician conducting a test
Psilocybin is a Schedule I substance in the United States, carrying significant legal risks.

Health Risks

While the use of psilocybin mushrooms doesn’t result in physical dependence, that doesn’t mean the symptoms you experience right after ingestion are any less dangerous and even life-threatening. These include:

  • increased blood rate and blood pressure
  • nausea, vomiting, diarrhea, and other digestive issues that can end up in dehydration
  • problems with coordination and balance

The most severe of these symptoms is increased blood rate and blood pressure. Especially in the case of people who already have cardiovascular conditions, one trip could easily cause them to have a heart attack and cost them their lives. The digestive symptoms can be severe in people with Crohn’s disease and other chronic digestive illnesses. People with liver damage should also stay away from using this substance. This is so because that organ metabolizes it. This can cause further damage or even failure.

Psychological Risks of Using Psilocybin Mushrooms and Treatment

Using psilocybin mushrooms can pose significant psychological risks, potentially leading to life-threatening situations. They may also exacerbate symptoms of mental illnesses such as depression, schizophrenia, and bipolar disorder. The hallucinations induced by psilocybin can trigger manic or depressive episodes, complicating these conditions.

Individuals with a history of substance use or disorders like ADHD, which increase the risk of addiction, should avoid psilocybin mushrooms. The reason is that psychological dependence on hallucinogenic mushrooms can develop, making it difficult to manage or quit their use. If this happens, programs such as substance abuse treatment in Pennsylvania can be a critical resource.

Seeking Help for Substance Use: Understanding the Impact of Psilocybin

If you are concerned about your substance use, especially regarding psilocybin mushrooms, it’s important to seek professional help. While shrooms and other psychedelic drugs are not typically addictive, they can become habit-forming and may signal a deeper issue with substance abuse. Understanding how long psilocybin stays in your system is just one part of addressing these concerns. If you find yourself frequently using shrooms despite negative consequences, it’s crucial to reach out for support. Little Creek Recovery is here to help with a free and confidential consultation. By reaching out, you can acquire essential tools, coping skills and support move towards a healthier and more balanced life. Contact us today to begin your journey to recovery.

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